公司动态
公司动态
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Murine VEGF165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Manufactured using all Animal-Free reagents.
Source:E.coli
Synonyms:Vascular Endothelial Growth Factor165, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A
AA Sequence (monomer):MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml.
Calculated Molecular Weight:39 kDa
Accession Number:Q00731
Gene ID:22339
Endotoxin:Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)